Participating centers

DETECT-1 study

Rationale: Out-of-hospital cardiac arrest (OHCA) is a leading cause of global mortality. Delays to initiation of cardiopulmonary resuscitation (CPR) should be as short as possible to achieve the highest survival chance. To reduce treatment delays automated cardiac arrest detection and call for help would be ideal. Photoplethysmography (PPG) is an optical technique often used in sport/smartwatches to monitor heart rhythm at the skin and based on previous studies it seems to have potential to detect circulatory arrest.
To study photoplethysmography signals during 1) induced circulatory arrest; 2) cardiac rhythms without circulatory arrest, and to construct a PPG-based algorithm for circulatory arrest detection.
Study design:
Prospective multicenter study.
Study population:
(1) Patients scheduled for defibrillation testing after (subcutaneous) implantable cardioverter defibrillator (ICD) implantation; 2) Patients undergoing transcatheter aortic valve implantation (TAVI) with intended rapid ventricular pacing; 3) Patients undergoing ventricular tachycardia ablation.
Patients will be equipped with a wristband with a PPG-sensor to record PPG signals during hospital stay including during induced circulatory arrests. The circulatory arrest inductions are part of routine practice during above-described procedures and are not a study-related intervention. In case this is not routine practice, an arterial line will be inserted as reference standard for circulatory arrest.
Primary endpoints:
Sensitivity and false positive alarms for circulatory arrest.
DETECT-1 Study protocol

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Afdeling cardiologie
Geert Grooteplein Zuid 10
6525 GA Nijmegen
DETECT 2023 | Gemaakt door Raion design